Can Senna Help Losing Weight?

From the study, we found that senna extract helps prevent cholesterol and triglyceride levels, which have increased in mice that have been fed a high-fat diet. Furthermore, senna also reduces the oxidation of lipids and nitric oxide production, which was controlled by senna extract in mice that received a high-fat diet by adding it.

In the mice’s liver, the red-stained sample provides further evidence that senna prevents inflammatory infiltration in cells, accumulation of fat droplets, and liver fibrosis in rats that have been fed a high-fat diet.  In addition, the extract can control fatty liver disease. Therefore, senna leaf extract has the property to inhibit inflammation of fatty liver and fibrosis, which suggests the benefit in the treatment of fatty hepatitis.

Picture 1 shows the results from the extract of senna leaves. The effects on hepatic lipid accumulation in mice that have been fed a high fat diet. A is the controlled group, B is the high fat diet group, C is the group that treated with 1% food, w/w of S. alexandrina leaf powder, D is the group that received fed a high fat diet and 1% food, w/w of S. alexandrina leaf powder, E is the group that have been fed a high fat diet with 10 mg/kg of atorvastatin, and F is the % of liver fat that has expanded at 40x magnification.

Picture 2 shows the results from senna leaf extract.  Effects on liver fibrosis in mice fed a high fat diet. A is the controlled group, B is the high fat diet group, C is the group that treated with 1% food, w/w of S. alexandrina leaf powder, D is the group that has been fed a high fat diet and 1% food, w/w of S. alexandrina leaf powder, E is the group that have been fed a high fat diet with 10 mg/kg of atorvastatin, and F is the % of liver fat that has expanded at 40x magnification.


The survey revealed benefits from senna leaf extract in mice that have been fed a high-fat diet but for long-term use of senna can have negative effects, mostly related to its laxative effect. Furthermore, senna leaf extract in controlled mice showed no adverse effects in terms of liver function.  In addition, the aforementioned extract also reduced the body weight of the controlled rats that was the result of reduced lipid accumulation in the controlled mice.